题目：Copper-Catalyzed Dual Remote Asymmetric VinylogousAlkynylallylic Substitution of Yne-Allylic Esters with Coumarins

作者:Xin-Ru Wang, Meng-Die Li, Zi-Han Wang, Hui Zhu, Jia-Run Wang, Ying-Ying Wei, and Tao-Yan Lin*

单位：Key Laboratory of Green and Precise Synthetic Chemistry and Applications, Ministry of Education, School of Chemistry and Materials Science, Huaibei Normal University, Huaibei, Anhui 235000, P. R. China

摘要：Chiral coumarins and their derivatives are ubiquitousstructural motifs found in an array of biologically andtherapeutically active natural products and drugs. Herein, a highlyenantioselective dual remote copper-catalyzed vinylogous alkynylallylicsubstitution of yne-allylic esters with coumarins has beendeveloped. The practicality of this method is exempliffed by the useof readily available starting materials; mild reaction conditions;excellent regio-, enantio-, and stereoselectivities; and the verybroad substrate scope (67 examples), while the scalability and further applications of this method are illustrated by the gram-scalereaction and the series of derivations of the products.

影响因子：4.9

分区情况：一区

链接：https://doi.org/10.1021/acs.orglett.4c02199

（文、图：林桃燕 / 审核：李洪基 / 审校：韩满意 / 终审：韩满意）